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Phenotype Image Detail
Image
Caption Light (A,B,E,F,I & J; x200) and electron (C,D,G,H,K. and L x5000) microscopy of kidneys from wild type and age matched Trove2tm1Woln/Trove2tm1Woln. Homozygous mutant and wild type mice from the original hybrid strain (A-D) were examined at 16.5 months, and backcrossed mice were examined at 7 (E-H) and 12.5 (I-L) months. Age matched wild type mice show essentially normal histology. The hybrid homozygous mutant mice show glomerular hypercellularity with large eosinophilic capillary deposits (B, arrow), which correspond to subendothelial immune complexes (D, arrow). Lesions in the backcrossed mice are less severe, with mesangial immune complexes at 7 months (H, arrow) and larger subendothelial complexes at 12.5 months (L, arrow).
Copyright This image is from Xue D, Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7503-8. Copyright 2003 National Academy of Sciences, U.S.A. J:84627
Associated
Alleles
Symbol Name
Trove2tm1Woln TROVE domain family, member 2; targeted mutation 1, Sandra L Wolin
Associated
Genotypes
Allelic Composition Genetic Background
Trove2tm1Woln/Trove2tm1Woln involves: 129S1/Sv * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory