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Phenotype Image Detail
Image
Caption Descending colon and rectum specimens A & B, show thickening of the intestinal wall and an absence of fecal pellets in the Runx3tm1Yg/Runx3tm1Yg mouse (right). H & E stained colon sections ( C & D) showing severe mucosal and submucosal thickening in the Runx3tm1Yg/Runx3tm1Yg (right) due to mixed inflammatory cellular indiltration with crypt hyperplasia and loss. Blue staining in the lamina propria (E & F) of the Runx3tm1Yg/Runx3tm1Yg reveals an abnormal deposition of collagen (arrow in F). Brown staining (G & H) shows an increase in proliferating cells in the crypts of the Runx3tm1Yg/Runx3tm1Yg cecum (right). Magnification: C-F: X10; G-H: X20
Copyright This image is from Brenner O, Proc Natl Acad Sci U S A 2004 Dec 9;101(45):16016-21. Copyright 2004 National Academy of Sciences, U.S.A. J:93240
Associated
Alleles
Symbol Name
Runx3tm1Yg runt related transcription factor 3; targeted mutation 1, Yoram Groner
Associated
Genotypes
Allelic Composition Genetic Background
Runx3tm1Yg/Runx3tm1Yg either: (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory