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Caption Development of collagen II induced arthritis (CIA) in Ncf1m1J/ Ncf1m1J mice carrying the H2q haplotype (**) compared with heterozygous (+*) and wild type (++) littermates. Mice were immunized with rat collagen II in CFA, injected intradermally at the base of the tail and boosted with an intradermal injection of collagen II in Freund's adjuvant at day 35. Panel A. Arthritis scores plotted against the different days after collagen II immunization. Panel B. Serum concentration of COMP used as a measure of ongoing cartilage destruction on days 40 and 102. Filled circles represent mice with arthritis and lines represent the mean values. #, fewer mice analyzed on day 102. Panel C. Morphological sections of ankle joints taken at day 102 after CIA induction. Sections were stained with hematoxylin and erythrosine (x100). Severe arthritis with cartilage and bone destruction in homozygous mice and milder destruction in heterozygotes and wild type control mice.
Copyright This image is from Hultqvist M, Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12646-51. Copyright 2004 National Academy of Sciences, U.S.A. J:92437
Associated
Alleles
Symbol Name
H2q histocompatibility-2, MHC; q variant
Ncf1m1J neutrophil cytosolic factor 1; mutation 1, Jackson
Associated
Genotypes
Allelic Composition Genetic Background
H2q/?
Ncf1m1J/Ncf1m1J
B6.Cg-Ncf1m1J H2q

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory