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Phenotype Image Detail
Image
Caption Fundus photographs, ERGs, and histology of eyes from Nr2e3rd7/Nr2e3rd7 mice at 1 month (a-c), 5 months (d-f), and 16 months (g-i) of age. At 1 month of age, Nr2e3rd7/Nr2e3rd7 mice have white spots over entire retina (a) but the scotopic and photopic (Inset) ERGs are normal (b), and light micrographs show photoreceptor and outer nuclear layerwaves, whorls, and rosettes in the retina (c). At about 5 months of age, the number of retinal spots is decreased (d), ERGs are still normal (e), and histology shows few retinal waves (f). By 16 months of age, attenuated retinal vessels and mottled retinal pigment indicate retinal degeneration (g), ERGs are now 50% of normal (h), and the outer nuclear layer and outer segment have degenerated to half normal (i).
Copyright This image is from Akhmedov NB, Proc Natl Acad Sci U S A 2000 May 9;97(10):5551-6. Copyright 2000 National Academy of Sciences, U.S.A. J:62171
Associated
Alleles
Symbol Name
Nr2e3rd7 nuclear receptor subfamily 2, group E, member 3; retinal degeneration 7
Associated
Genotypes
Allelic Composition Genetic Background
Nr2e3rd7/Nr2e3rd7 Not Specified

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory