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| Caption | Generation of the Gpx5tm1115.1Arte and Gpx5tm1115.2Arte alleles. (A) Schematic representation of mouse Gpx5 gene organization. Top: Gray boxes (E1 to E5) indicate the 5 GPX5 coding exons. Black arrows point to in-frame ATG translational start sites. Arrowheads indicate the relative positions of the various primers used in PCR amplification. Numbers (in bp) at the boundaries of each exon correspond to the GenBank Gpx5 sequence (accession number NM_010343), with "1" indicating the cap site. Bottom: A scheme of the targeting vector and the resulting allele is shown. In vivo Cre mediated excision of the Gpx5 exon 2 led to a premature translation frameshift. | ||||||
| Copyright | This image is from Chabory E, J Clin Invest 2009 Jul;119(7):2074-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152563 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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