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| Caption | Generation of the Col6a3tm1Chu allele. A. Gene targeting of Col6a3. The targeting vector contains a 5.4-kb HindIII (H) fragment as a long arm, a 2.5-kb HindIII fragment as the short arm, and a Pgk-Neo gene flanked by LoxP sequences replacing a HindIII fragment spanning from exon 15 to intron 16 of the Col6a3 gene. The targeted region encodes two VWA modules in the N-globular domain (N1 and N2) and the N-terminal half of the triple-helical domain (TH) of the Col6a3 protein. Restriction sites shown are BglI. E, aberrant splicing of the targeted allele. The splice acceptor site in exon 15 of the targeted allele was not used, resulting in skipping of exons 15 and 16 in the mutant mRNA. | ||||
| Copyright | This image is from Pan TC, J Biol Chem 2013 May 17;288(20):14320-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198581 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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