Phenotype Image Detail

Image

Caption

Loss of TTC8 adversely affects glomerular formation in Ttc8^tm1Reed/Ttc8^tm1Reed Or10a4^tm1Mom/Or10a4⁺ neonatal pups. (A) (Left) X-Gal-stained section through a medial P2 glomerulus from a control PD1 mouse reveals a tight convergence of axons. (Right) Section from the same region of a Ttc8^tm1Reed/Ttc8^tm1Reed Or10a4^tm1Mom/Or10a4⁺ mutant littermate shows reduced axonal convergence. (B) Glomerular targeting efficiency was quantified by using a 0-5 scale, where 0 represented no axonal convergence and 5 represented convergence to a single, tightly circumscribed glomerulus. Scorers were blind to genotype and instructed not to take into account the number or intensity of stained fibers. Scores were averaged for each genotype; error bars represent SD, and numbers within the bars indicate the number of glomeruli scored. *P<0.01 vs. control.

Copyright

This image is from Tadenev AL, Proc Natl Acad Sci U S A 2011 Jun 21;108(25):10320-5. Copyright 2011 National Academy of Sciences, U.S.A. J:173465

Associated Alleles

Symbol	Name
Or10a4^tm1Mom	olfactory receptor family 10 subfamily A member 4; targeted mutation 1, Peter Mombaerts
Ttc8^tm1Reed	tetratricopeptide repeat domain 8; targeted mutation 1, Randall R Reed

Associated Genotypes

Allelic Composition	Genetic Background
Or10a4^tm1Mom/Or10a4^+ Ttc8^tm1Reed/Ttc8^tm1Reed	involves: 129 * 129P2/OlaHsd * C57BL/6