Phenotype Image Detail

Image

Caption

Rod outer segment (ROS) structures in wild-type (WT) and Rho^tm1.1Kpal/Rho⁺ (P23H/+) mice. Transmission electron micrographs (TEM) of ROS from WT (A and A') and heterozygous mutant (B-F, B' and C') mice. Images were taken from postnatal day (PND) 63 littermates. Disorganization of ROS was observed in all three analyzed P23H/+ mice (B, C, and D) as perpendicularly placed discs (arrows) or elongated discs (arrowheads). C, E, and F retinal images were obtained from one mouse to show disorganization at the incisure (C) and base of ROS (E) and both types of disorganization in a single OS (F). Lower magnification images of A-C are shown in A'-C'. Arrows correspond to perpendicularly placed discs. Arrowheads, perpendicularly placed elongated discs. Open arrowheads, vesicles. Open arrow in C, an incisure.

Copyright

This image is from Sakami S, J Biol Chem 2011 Mar 25;286(12):10551-67 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:170648

Associated Alleles

Symbol	Name
Rho^tm1.1Kpal	rhodopsin; targeted mutation 1.1, Krzysztof Palczewski

Associated Genotypes

Allelic Composition	Genetic Background
Rho^tm1.1Kpal/Rho^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N