Phenotype Image Detail

Image

Caption

Adult tail phenotypes of 5 kL (5kL-1/0: Tg(Lfng-LFNG)1Dihz/0 Lfng^tm1Rjo/Lfng^tm1Rjo, 5kL-2: Tg(Lfng-LFNG)2Dihz/? Lfng^tm1Rjo/Lfng^tm1Rjo) and BBL (BBL-1/BBL-1: Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz Lfng^tm1Rjo/Lfng^tm1Rjo) trasngenes and Hes7^tm1.1Dihz/Hes7^tm1.1Dihz (Hes7^BAP/BAP) knock-in mice. Transgenic mice of the 5 kL lines (without endogenous Lfng) resemble wild-type and heterozygous Lfng^tm1Rjo ( lfng^+/-) mutant mice; BBL lines (without endogenous Lfng) show a tail rescue of variable degree (A, arrowheads point at kinks). Heterozygous Hes7^tm1.1Dihz (Hes7^BAP/+) mice resemble wild-type; Hes7^tm1.1Dihz/Hes7^tm1.1Dihz mice have truncated, kinky tails (B).

Copyright

This image is from Stauber M, PLoS One 2009;4(11):e7996, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155378

Associated Alleles

Symbol	Name
Hes7^tm1.1Dihz	hes family bHLH transcription factor 7; targeted mutation 1.1, David Ish-Horowicz
Lfng^tm1Rjo	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Randy L Johnson
Tg(Lfng-LFNG)1Dihz	transgene insertion 1, David Ish-Horowicz
Tg(Lfng*-LFNG)1Dihz	transgene insertion 1, David Ish-Horowicz
Tg(Lfng-LFNG)2Dihz	transgene insertion 2, David Ish-Horowicz

Associated Genotypes

Allelic Composition	Genetic Background
Lfng^tm1Rjo/Lfng^tm1Rjo	involves: 129S7/SvEvBrd
Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz	involves: 129S7/SvEvBrd * C57BL/6J * CBA
Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)1Dihz/0	involves: 129S7/SvEvBrd * C57BL/6J * CBA
Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)2Dihz/?	involves: 129S7/SvEvBrd * C57BL/6J * CBA
Hes7^tm1.1Dihz/Hes7^tm1.1Dihz	Not Specified