Phenotype Image Detail

Image

Caption

Morphological brain anomalies in Wdfy3^disc/Wdfy3^disc (disc/disc) mutants. (a) Lateral views of whole-mount heterozygous and homozygous disc brains illustrate the morphological anomalies of the homozygous mutant. The yellow lines and asterisk indicate the enlargement of the most anterior aspect of cerebral cortex (Cx). Notice also the considerably smaller olfactory bulb (OB) in the homozygous mutant. (b) Parasagittal Nissl-stained sections of heterozygous and homozygous mutant show an enlargement of the frontopolar cortex, cortical thinning at anterior aspects, diminished olfactory bulb, and enlargement of the lateral ventricles (LV). Close-ups of anterior cortical segments on the right confirm cerebral thinning and lamination defects leading to a reduction of the ventricular/subventricular zones (VZ/SVZ) and loss of the subplate (SP). Cb, cerebellum; CC, corpus callosum; HC, hippocampus; MB, midbrain; MZ, marginal zone; St, striatum. Scale bars in B are 500 um and 50 um respectively.

Copyright

This image is from Orosco LA, Nat Commun 2014;5():4692, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:225200

Associated Alleles

Symbol	Name
Wdfy3^disc	WD repeat and FYVE domain containing 3; disconnected

Associated Genotypes

Allelic Composition	Genetic Background
Wdfy3^disc/Wdfy3^disc	involves: C57BL/6J * FVB/NJ