Phenotype Image Detail

Image

Caption

Displaced tongue position obstructs palatal elevation in Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0 mutants. B, skeletal preparations show the shorter mandibles in Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0 (Sox11^Ella-Cre) compared with wild-type (Wt) mice. Scale bars = 1 mm. D, histological staining on sections of embryonic head explants by in vitro rolling culture. The elevation of palatal shelves is achieved either by removal of the tongue or removal of the mandible. Arrows point to the comparable horizontal positions in mutant and wild-type controls. Ps, palatal shelf.

Copyright

This image is from Huang H, J Biol Chem 2016 Mar 25;291(13):7107-18 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:232434

Associated Alleles

Symbol	Name
Sox11^tm1.1Gan	SRY (sex determining region Y)-box 11; targeted mutation 1.1, Lin Gan
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N