Phenotype Image Detail

Image

Caption

(B) Representative explanted wild-type (WT-cre), Mtor^tm1.1Gcon/Mtor^tm1.1Gcon (F/F) control, and Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 (Mtor-cKO) mutant hearts. The mutant heart is larger than that of controls. (C) Representative H&E-stained heart sections. Mutant hearts have thinned ventricular walls and enlarged cardiac chambers.

This image is from Zhang D, J Clin Invest 2010 Aug 2;120(8):2805-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:163763

Associated
Alleles

Symbol	Name
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}	APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin
Mtor^tm1.1Gcon	mechanistic target of rapamycin kinase; targeted mutation 1.1, Gianluigi Condorelli

Associated
Genotypes

Allelic Composition	Genetic Background
Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

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