Phenotype Image Detail

Image

Caption

(A-H) Six1^tm1Mair/Six1^tm1Mair Eya1^tm1Rilm/Eya1^tm1Rilm mutants (E-H) had hypoplastic outflow tract (OFT) cushions compared with wild-type (WT) littermate controls (A-D). Shown are serial histological sections of E11.5 outflow vessels proceeding from proximal (A and E) to distal (D and H). Brackets in A-D indicate wild-type OFT cushions, which were hypoplastic in the mutants (asterisks). Myo, myocardium.

Copyright

This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023

Associated Alleles

Symbol	Name
Eya1^tm1Rilm	EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
Six1^tm1Mair	sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
Tbx1^tm1Bem	T-box 1; targeted mutation 1, Bernice E Morrow

Associated Genotypes

Allelic Composition	Genetic Background
Eya1^tm1Rilm/Eya1^tm1Rilm Six1^tm1Mair/Six1^tm1Mair	involves: 129S1/Sv * 129X1/SvJ * C57BL/6