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Phenotype Image Detail
Image
Caption (C) H&E section of control spleen. (D) H&E section of Notch1tm2Rko/Notch1tm3(cre)Rko spleen. Mutant animals show reactive splenomegaly to the inflammation in the liver, featured by the marked expansion of the interfollicular compartments and extra-medullary hematopoiesis of granulocytic, erythrocytic and megakaryotic lineages.
Copyright This image is from Liu Z, J Clin Invest 2011 Feb 1;121(2):800-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171829
Associated
Alleles
Symbol Name
Notch1tm2Rko notch 1; targeted mutation 2, Raphael Kopan
Notch1tm3(cre)Rko notch 1; targeted mutation 3, Raphael Kopan
Associated
Genotypes
Allelic Composition Genetic Background
Notch1tm2Rko/Notch1tm3(cre)Rko involves: 129X1/SvJ * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory