Phenotype Image Detail

Image

Caption

E155G mutation in Guca1a (GCAP1) causes photoreceptor degeneration. Photomicrographs of resin-embedded sections from (a) wild-type, (b) Guca1a^tm1.1Hunt/Guca1a⁺ (Guca1a^+/COD3), and (c) Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt (Guca1a^COD3/COD3) mice at five months of age. There is a marked thinning of the outer nuclear layer (ONL) in mutant eyes as shown by the loss of photoreceptor nuclei. There is also an apparent shortening of outer segment length, particularly in the homozygous mutant mice. Photoreceptor loss in heterozygous and homozygous mutant mice was quantified by counting photoreceptor nuclei in photomicrographs of sections from paraffin-embedded eyes taken at fixed positions around the optic nerve.

Copyright

This image is from Buch PK, PLoS One 2011;6(3):e18089, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171667

Associated Alleles

Symbol	Name
Guca1a^tm1.1Hunt	guanylate cyclase activator 1a (retina); targeted mutation 1.1, David M Hunt

Associated Genotypes

Allelic Composition	Genetic Background
Guca1a^tm1.1Hunt/Guca1a^+	involves: 129
Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt	involves: 129