Phenotype Image Detail

Image

Caption

Plaque-associated tau pathology in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 (rTg9191) mice. Brain sections from mutant mice of 24 months of age (B, F, J, N, R, V, Z), their age-matched non-transgenic littermates (A, E, I, M, Q, U, Y), 23-month-old mutant mice (C, G, K, O, S, W, AA) and 15-month-old mutant mice (D, H, L, P, T, X, AB) were stained with a variety of antibodies directed against pathological conformation- and phosphorylation dependent epitopes of tau: AT8 (A-D), CP13 (E-H), PG5 (I-L), PHF-1 (M-P), Alz50 (Q-T), MC1 (U-X) and TG-3 (Y-AB). Representative photomicrographs showed that hyperphosphorylated and/or misfolded tau proteins accumulated (brown puncta) around dense-core plaques visualized using Congo red (pink). Neuronal staining (brown) in mutant mice served as positive control. Scale bars: 20 um. Images in the same row have the same magnification. Representative photomicrographs show tau pathology of female mice, and similar results were found in male mice.

Copyright

This image is from Liu P, PLoS One 2015;10(5):e0126317, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:235351

Associated Alleles

Symbol	Name
Tg(Camk2a-tTA)1Mmay	transgene insertion 1, Mark Mayford
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz	transgene insertion 9191, Kathleen R Zahs

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0	involves: 129S6/SvEvTac * FVB/N