Phenotype Image Detail

Image

Caption

Age-related amyloid beta plaque progression in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 (rTg9191) mice. (A) A representative sagittal section of brain. Black rectangles indicate the regions of cerebral cortex and hippocampal formation in which amyloid beta plaques are shown in (B-E). (B-E) Representative photomicrographs showing age-dependent progression of amyloid beta plaques in female mice, visualized using 6E10 (B); 4G8, directed against a mid-region of amyloid beta (C); 139-5, an amyloid beta x-40-specific antibody (D); and 1-11-3, an amyloid beta x-42-specific antibody (E). Upper panels, cerebral cortex; lower panels, hippocampus. Scale bars: 100 um (upper panels), 200 um (lower panels). TTA, mice expressing only the tetracycline transactivator. (F) Quantification of 4G8-immunoreactive amyloid beta plaque load at various ages.

Copyright

This image is from Liu P, PLoS One 2015;10(5):e0126317, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:235351

Associated Alleles

Symbol	Name
Tg(Camk2a-tTA)1Mmay	transgene insertion 1, Mark Mayford
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz	transgene insertion 9191, Kathleen R Zahs

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0	involves: 129S6/SvEvTac * FVB/N