Phenotype Image Detail

Image

Caption

Representative images of the lungs and hearts (top and middle, respectively), and histological cross-sections of the hearts (H&E staining, bottom) of the Npr1^tm1.1Kkan/Npr1^tm1.1Kkan (GC-A^flox/flox; control) and Npr1^tm1.1Kkan/Npr1^tm1.1Kkan Tg(Tek-cre)1Ywa/0 (EC GC-A-KO) mice after injection of B16/F10 cells (2 X 10⁵ cells per mouse). The mice were killed 2 weeks after the injection of the tumor cells. (Scale bars, 500 um.) Red arrows indicate metastasis in the heart.

Copyright

This image is from Nojiri T, Proc Natl Acad Sci U S A 2015 Mar 31;112(13):4086-91. Copyright 2015 National Academy of Sciences, U.S.A. J:220676

Associated Alleles

Symbol	Name
Npr1^tm1.1Kkan	natriuretic peptide receptor 1; targeted mutation 1.1, Kenji Kangawa
Tg(Tek-cre)1Ywa	transgene insertion 1, Masashi Yanagisawa

Associated Genotypes

Allelic Composition	Genetic Background
Npr1^tm1.1Kkan/Npr1^tm1.1Kkan Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL