Phenotype Image Detail

Image

Caption

The large intestine of Neurog3^tm1Fgu/Neurog3^tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3^tm3.1Ggr/Neurog3^tm3.1Ggr Tg(Vil1-cre)20Syr/0 (mutant) mice shows shorter glands. Sections of adult wild-type (A and C) and mutant (B and D) large intestine were examined for their overall appearance (A and B) and the presence of goblet cells (C and D). (A and B) H&E staining clearly shows the reduction in the length of the glands in the large intestine of mutant mice (B, measurement in E) compared with control tissue. (C and D) Periodic acid-Schiff staining of goblet cells. (E) The colonic glands in mutant animals are on average 26% shorter than the colonic glands of control animals (n = 4; 50-60 glands were analyzed per genotype). **P < 0.01. The age of the animals analyzed is 10-12 weeks.

Copyright

This image is from Mellitzer G, J Clin Invest 2010 May 3;120(5):1708-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:161480

Associated Alleles

Symbol	Name
Neurog3^tm1Fgu	neurogenin 3; targeted mutation 1, Francois Guillemot
Neurog3^tm3.1Ggr	neurogenin 3; targeted mutation 3.1, Gerard Gradwohl
Tg(Vil1-cre)20Syr	transgene insertion 20, Sylvie Robine

Associated Genotypes

Allelic Composition	Genetic Background
Neurog3^tm1Fgu/Neurog3^tm3.1Ggr Tg(Vil1-cre)20Syr/0	involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL
Neurog3^tm3.1Ggr/Neurog3^tm3.1Ggr Tg(Vil1-cre)20Syr/0	involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL