Phenotype Image Detail

Image

Caption

Flnb^tm1Vshn/Flnb^tm1Vshn (FlnB^-/-) mice display skeletal shortening and abnormalities in the growth plates of the appendicular bones. (A) Gross specimen of 4 week old radius from mutant and control mice following Alizarin red (calcified bone) and Alcian blue (cartilage) staining. The forearm length is reduced in the knockout and quantified to the right. (B) Hematoxylin and eosin (H&E) staining reveals that the reduction in bone length in the radius of P1 and P7 mutant mice is due to thinning of the growth plates compared to wild-type (WT). Quantification at these postnatal ages is graphically shown to the right. For all experiments, n samples > or = 3 per variable, *= p< 0.05, **=p<0.01, ***= p<0.001 by t-test. Scale bar= 200 um for B.

Copyright

This image is from Hu J, PLoS One 2014;9(2):e89352, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:213355

Associated Alleles

Symbol	Name
Flnb^tm1Vshn	filamin, beta; targeted mutation 1, Volney Sheen

Associated Genotypes

Allelic Composition	Genetic Background
Flnb^tm1Vshn/Flnb^tm1Vshn	involves: 129S6/SvEvTac * C57BL/6