Phenotype Image Detail

Image

Caption

Cep290^{Gt(CC0582)Wtsi}/Cep290^{Gt(CC0582)Wtsi} (Cep290^LacZ/LacZ) mice exhibit progressive renal collecting duct cystic disease. Representative kidney sections from wild-type (Cep290^+/+) (Upper) and mutant mice (Lower) stained with hematoxylin/eosin. Microcysts are present in mutant kidneys from birth to 1 year (A, and magnified in B) at birth (P0), (C) 2 weeks (P14), and (D) 1 year (1 yr) of age. The asterisk highlights collecting duct cysts, and arrows indicate the epithelial cell layer lining of a cyst. (Scale bars: A, 500 um; B, 50 um; C and D, 500 um.)

Copyright

This image is from Hynes AM, Proc Natl Acad Sci U S A 2014 Jul 8;111(27):9893-8. Copyright 2014 National Academy of Sciences, U.S.A. J:212182

Associated Alleles

Symbol	Name
Cep290^Gt(CC0582)Wtsi	centrosomal protein 290; gene trap CC0582, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Cep290^Gt(CC0582)Wtsi/Cep290^Gt(CC0582)Wtsi	129P2/OlaHsd-Cep290^Gt(CC0582)Wtsi