Phenotype Image Detail

Image

Caption

Representative magnetic resonance images (MRI) of AAV1-CBA-Cre and AAV1-CBA-GFP injected Tsc1^tm1Djk/Tsc1^tm1Djk Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ mouse brains. AAV1-CBA-Cre injected mouse brains showed abnormalities associated with the ventricular regions. (A) Multiple apparent subependymal nodules (arrowheads) were seen in the ventricles in the brains of two AAV1-CBA-Cre injected mice. First two images are from the same mouse. (B) Ventricles also appeared to have thickening of the ependymal lining (arrowheads; two left panels). (C) None of these abnormalities were observed in the control vector (AAV1-CBA-GFP)-injected brains

Copyright

This image is from Prabhakar S, PLoS One 2013;8(5):e64224, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:221022

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1Sho	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Stuart Orkin
Tsc1^tm1Djk	TSC complex subunit 1; targeted mutation 1, David J Kwiatkowski

Associated Genotypes

Allelic Composition	Genetic Background
Tsc1^tm1Djk/Tsc1^tm1Djk Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * 129S4/SvJaeSor