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Caption Defective synapsis of the homologous chromosomes in Lmnatm1Rben/Lmnatm1Rben (Lamin C2-/-) meiocytes. Representative chromosome spreads of spermatocytes (A) and oocytes (17.5 dpf) (B) labelled with anti-SYCP3 and anti-SYCP1 antibodies. Heterologous associations (red box in A') are observed in mutant spermatocytes only. Incomplete pairing of homologs (white boxes in A' and B') as well as univalent chromosomes (arrowheads in A", A'" and B") occur in both mutant spermatocytes and oocytes. Mutant spermatocytes also display cells with X and Y chromosomes as the only univalents (arrowheads in A'") or with linear telomere-telomere associations between non-homologous chromosomes (arrow in A""). Scale bars 10 um. (C) Quantification of meiocytes with defective synapsis in mutant males and females. For both sexes, differences between mutants and controls are highly significant (Pearson's Chi2 test p-value<0.0001 each) (D) Synaptic pairing defects in males were further categorised and quantified. Interestingly, sex chromosomes were univalent in the vast majority of mutant spermatocytes.
Copyright This image is from Link J, PLoS Genet 2013;9(1):e1003261, an open-access article distributed under the terms of the Creative Commons Attribution License. J:223056
Symbol Name
Lmnatm1Rben lamin A; targeted mutation 1, Ricardo Benavente
Allelic Composition Genetic Background
Lmnatm1Rben/Lmnatm1Rben involves: 129S1/Sv * 129X1/SvJ

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