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Phenotype Image Detail
Image
Caption Golgi images of dendritic spines in the apical and basal dendrites of control (CTL), Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSWT) and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSR521G) mice. Spine density was analyzed in a total of 30 neurons from cortical layers IV-V in P18 Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSWT) and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSR521G) mice and their corresponding littermate controls (n = 3 mice per group). In Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSWT) mice the density of mature dendritic spines does not differ in apical and basal dendrites. However, in Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSR521G) mice the density of mature dendritic spines is reduced in the apical and secondary dendrites compared with littermate controls. (We have defined "mature" spines as being mushroom-shaped.) Arrowheads indicate immature spines.
Copyright This image is from Sephton CF, Proc Natl Acad Sci U S A 2014 Nov 4;111(44):E4769-78. Copyright 2014 National Academy of Sciences, U.S.A. J:216672
Associated
Alleles
Symbol Name
Meox2tm1(cre)Sor mesenchyme homeobox 2; targeted mutation 1, Philippe Soriano
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu transgene insertion 629, Gang Yu
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu transgene insertion 682, Gang Yu
Associated
Genotypes
Allelic Composition Genetic Background
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
involves: 129S4/SvJaeSor * C57BL/6
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
involves: 129S4/SvJaeSor * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory