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Phenotype Image Detail
Image
Caption Increased distal convoluted tubule (DCT) fractional volume in Wnk1tm2.1Juha/Wnk1+ Tg(Pgk1-cre)1Lni/0 (WNK1+/FHHt) mice. Representative images of Na+-Cl- cotransporter (NCC) immunostaining in (Upper Left) Wnk1tm2.1Juha/Wnk1+ (WNK1+/i1lox) and (Upper Right) WNK1+/FHHt kidney sections. (Lower) DCT fractional volume, quantified as the number of intersections between DCTs (identified as NCC-positive nephron segments) and a 50-um grid, is increased in WNK1+/FHHt mice. Individual data are plotted, and the bar corresponds to the median. *P < 0.05 (Mann-Whitney nonparametric ranking test).
Copyright This image is from Vidal-Petiot E, Proc Natl Acad Sci U S A 2013 Aug 27;110(35):14366-71. Copyright 2013 National Academy of Sciences, U.S.A. J:200742
Associated
Alleles
Symbol Name
Tg(Pgk1-cre)1Lni transgene insertion 1, Peter Lonai
Wnk1tm2.1Juha WNK lysine deficient protein kinase 1; targeted mutation 2.1, Juliette Hadchouel
Associated
Genotypes
Allelic Composition Genetic Background
Wnk1tm2.1Juha/Wnk1+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory