Phenotype Image Detail

Image

Caption

B-cell leukemia identified in a Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ mouse. (B) Wright's stain on peripheral blood smears showing lymphoblast cluster from a homozygous mutant mouse (ii) compared with a healthy control littermate (i). Leukocytes featured as large-sized undifferentiated hematopoietic cells with a small basophilic cytoplasm and visible nucleoli (Scale = 20 mm). (C) Lymphocytic leukemia involving the liver. Representative images of Hematoxylin and eosin stained sections (upper panel) and immunohistochemical staining of B220 or Cd3 (lower panel) showing periportal infiltration by B-lymphocytes (Scale = 50 mm). (D) Effacement of the lymph node architecture. Low-power (upper panel) and enlarged views (lower panel) show a periportal lymphocytic infiltrate in the lymph node (Scale = 50 mm).

Copyright

This image is from Shi W, PLoS Genet 2013 Feb;9(2):e1003298, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195140

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm9(cre/ESR1)Arte	gene trap ROSA 26, Philippe Soriano; targeted mutation 9, TaconicArtemis
Nabp2^tm1.1Kkha	nucleic acid binding protein 2; targeted mutation 1.1, Kum Kum Khanna

Associated Genotypes

Allelic Composition	Genetic Background
Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha Gt(ROSA)26Sor^tm9(cre/ESR1)Arte/Gt(ROSA)26Sor^+	involves: C57BL/6 * C57BL/6NTac