Phenotype Image Detail

Image

Caption

Broad tumour spectrum in Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}Gt(ROSA)26Sor⁺ mice. (C) Representative sections have T lymphoma in thymus (top panel) and B lymphomas in spleen (middle panel), which spread to lung in a mutant mouse (bottom panel). Representative images of Haematoxylin and eosin stained sections of tumours in indicated organs are shown. Immunohistochemical staining of Cd3 (top panel, right) confirmed T-cell lymphoma in thymus (Scale bars, i = 40 mm, ii = 120 mm, iii = 20 mm, iv = 40 mm, v = 60 mm, vi = 80 mm). (D) Representative image of liver cancer (hepatocellular carcinoma, HCC) in a mutant mouse. Representative images of tumour mass (upper panel) and Haematoxylin and eosin-stained liver section (middle and lower panels) are shown (Scale bars, ii = 100 mm, iii = 140 mm).

Copyright

This image is from Shi W, PLoS Genet 2013 Feb;9(2):e1003298, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195140

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm9(cre/ESR1)Arte	gene trap ROSA 26, Philippe Soriano; targeted mutation 9, TaconicArtemis
Nabp2^tm1.1Kkha	nucleic acid binding protein 2; targeted mutation 1.1, Kum Kum Khanna

Associated Genotypes

Allelic Composition	Genetic Background
Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha Gt(ROSA)26Sor^tm9(cre/ESR1)Arte/Gt(ROSA)26Sor^+	involves: C57BL/6 * C57BL/6NTac