Phenotype Image Detail

Image

Caption

Yap loss of function impairs neonatal heart regeneration. Cardiac fibrosis and scar formation were compared in control Yap1^tm1.1Eno/Yap1^tm1.1Eno (Yap^fl/fl) and Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO) mice. Hearts were subjected to left anterior descending coronary artery (LAD) ligation at P2 and analyzed by Masson's trichrome staining of transverse sections at P28. Shown are the site of ligation (marked with an "X") and the four levels at which cardiac fibrosis was evaluated. Serial sections were cut at 200-um intervals from the site of the ligature toward the apex. Three hearts of each genotype were examined; representative hearts are shown. The boundaries of the infarct zones are demarcated by the V-shaped lines on the right.

Copyright

This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670

Associated Alleles

Symbol	Name
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider
Yap1^tm1.1Eno	yes-associated protein 1; targeted mutation 1.1, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N