Phenotype Image Detail

Image

Caption

Osteopenia in Pkd1^tm1Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0 (Col1a1(3.6)-Cre;Pkd1^flox/null) newborn mice but not in Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0 (Col1a1(3.6)-Cre;Pkd1^flox/flox) newborns. The whole skeleton mineralization (A and B), full-length mineralized femurs (C and D), bone volume of metaphyseal region (E and F), and cortical thickness of cortical bone (G and H) of femurs from Tg(Col1a1-cre)1Bek/0 Pkd1^tm2Ggg/Pkd1^tm2Ggg (Col1a1(3.6)-Cre;Pkd1^flox/flox) and Tg(Col1a1-cre)1Bek/0 Pkd1^tm1Ggg/Pkd1^tm2Ggg (Col1a1(3.6)-Cre;Pkd1^flox/null) newborn mice by microCT analysis. A Pkd1 gene dose effect was observed during skeletogenesis between Tg(Col1a1-cre)1Bek/0 Pkd1^tm2Ggg/Pkd1^tm2Ggg and Tg(Col1a1-cre)1Bek/0 Pkd1^tm1Ggg/Pkd1^tm2Ggg mice. Data represent the mean +/- S.D. from three to four individual samples. *Significant difference from control mice at P<0.05.

Copyright

This image is from Qiu N, PLoS One 2012;7(9):e46038, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191967

Associated Alleles

Symbol	Name
Pkd1^tm1Ggg	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Gregory G Germino
Pkd1^tm2Ggg	polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Gregory G Germino
Tg(Col1a1-cre)1Bek	transgene insertion 1, Barbara E Kream

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0	involves: 129S4/SvJae * CD-1
Pkd1^tm1Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0	involves: 129S4/SvJae * CD-1