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Phenotype Image Detail
Image
Caption (A) Pkd1tm1.1Pcha/Pkd1tm1Shh (Pkd1RC/del2) animals develop anosteopenia like phenotype characterized by a significant decrease in cortical (left microCT image + graph) and trabecular (right microCT image) bone mass - a phenotype known to be associated with a reduction of Pkd1 in mice. BV: Bone volume, TV: Tissue volume. Statistical values were obtained by Student t-test (*p<0.05, ***p<0.001); error bars indicate +/- SD.
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Associated
Alleles
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Pkd1tm1Shh polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Shigeo Horie
Associated
Genotypes
Allelic Composition Genetic Background
Pkd1tm1Shh/Pkd1tm1.1Pcha involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory