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Phenotype Image Detail
Image
Caption Detailed illustration of disease variation among non-littermate Pkd1tm1.1Pcha/Pkd1tm1Shh (Pkd1RC/del2) animals at various time points. Masson Trichrome stained histology sections of one wild-type and two non-littermate mutant animals at various ages. Cyst burden progressively increased with age until P25. Subsequently, the kidneys become highly fibrotic (P180). The model shows only moderate disease variability among animals. Scale bars: E14.5 and E16.5 = 150 um. E18.5 and P1 = 250 um. P6 and P9 = 500 um, P12 and P15 - 750 um, P18 to P180 = 1mm.
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Associated
Alleles
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Pkd1tm1Shh polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Shigeo Horie
Associated
Genotypes
Allelic Composition Genetic Background
Pkd1tm1Shh/Pkd1tm1.1Pcha involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory