Phenotype Image Detail

Image

Caption

Detailed illustration of disease variation among non-littermate Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) animals at various time points. Masson Trichrome stained histology sections of one wild-type and two non-littermate mutant animals at various ages. Cyst burden progressively increased with age until P25. Subsequently, the kidneys become highly fibrotic (P180). The model shows only moderate disease variability among animals. Scale bars: E14.5 and E16.5 = 150 um. E18.5 and P1 = 250 um. P6 and P9 = 500 um, P12 and P15 - 750 um, P18 to P180 = 1mm.

Copyright

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6