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Phenotype Image Detail
Caption Homozygosity of the Pkd1tm1.1Pcha (Pkd1 p.R3277C) allele results in progressive polycystic kidney disease (PKD) with physiological characteristics comparable to those of human Autosomal Dominant Polycystic Kidney Disease (ADPKD). (A) Representative US M-mode images of Pkd1tm1.1Pcha/Pkd1tm1.1Pcha mice. Kidneys with the mildest (left) and most severe disease (right) are shown at 3 months. Kidney cysts are visible as echolucent spots (arrows). Scale bars: 10 mm (left); 12 mm (right).
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Allelic Composition Genetic Background
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha involves: 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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