Phenotype Image Detail

Image

Caption

Homozygosity of the Pkd1^tm1.1Pcha (Pkd1 p.R3277C) allele results in progressive polycystic kidney disease (PKD) with physiological characteristics comparable to those of human Autosomal Dominant Polycystic Kidney Disease (ADPKD). (A) Representative US M-mode images of Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha mice. Kidneys with the mildest (left) and most severe disease (right) are shown at 3 months. Kidney cysts are visible as echolucent spots (arrows). Scale bars: 10 mm (left); 12 mm (right).

Copyright

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha	involves: 129S1/Sv * C57BL/6