Phenotype Image Detail

Image

Caption

Branching morphogenesis in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ (Yap^CM-/-) mice. Staining for Calbindin at E14.5 shows similar number of epithelial tips at E14.5 (A,B), while branching is severely decreased in hypoplastic mutant kidneys at P0 (C,D). Slides were counterstained with DAPI. (E) Calbindin staining was used to quantify branching morphogenesis in control (black columns) and mutant (white columns) at E14.5, E16.5 (*p=0.0369) and P0 (***p<0.001). Scale bars represent 500 um.

Copyright

This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266

Associated Alleles

Symbol	Name
Six2^tm1(tTA,tetO-EGFP/cre)Amc	sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Yap1^tm1Hmc	yes-associated protein 1; targeted mutation 1, Helen McNeill

Associated Genotypes

Allelic Composition	Genetic Background
Yap1^tm1Hmc/Yap1^tm1Hmc Six2^tm1(tTA,tetO-EGFP/cre)Amc/Six2^+	involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl