Phenotype Image Detail

Image

Caption

Yap1 and Wwtr1 have distinct roles during nephrogenesis. (A-D) Macroscopic view of the urogenital systems from wild-type, Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ (Taz^CM-/-), Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ (Yap^CM-/-), and Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ (Taz^CM-/-;Yap^CM-/-) double mutant kidneys at P0. (E-H) PAS staining of P0 kidneys. (I-L) Closer view of the cortical zones. (M-P) LTL staining for each genotype. (Q-T) NCAM staining for all genotypes. (U-X) Six2 staining reveals progenitor cell population in all genotypes. Scale bars represent 500 um (A-H) and 100 um (I-X).

Copyright

This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266

Associated Alleles

Symbol	Name
Six2^tm1(tTA,tetO-EGFP/cre)Amc	sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
Wwtr1^tm1Hmc	WW domain containing transcription regulator 1; targeted mutation 1, Helen McNeill
Yap1^tm1Hmc	yes-associated protein 1; targeted mutation 1, Helen McNeill

Associated Genotypes

Allelic Composition	Genetic Background
Yap1^tm1Hmc/Yap1^tm1Hmc Six2^tm1(tTA,tetO-EGFP/cre)Amc/Six2^+	involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Six2^tm1(tTA,tetO-EGFP/cre)Amc/Six2^+	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J