Phenotype Image Detail

Image

Caption

Gross morphology of the inner ear at P20 after clearing with glycerol. Front and back views from wild-type (+/+) (C and E) and Atp6v0a4^tm1.1Fekf/Atp6v0a4^tm1.1Fekf (-/-, D and F) mice are shown. In the mutants, the cochlear duct is expanded compared with controls (C and D) (white arrowheads). Their endolymphatic ducts are abnormally enlarged (E and F) (red arrowheads), with a lack of visible otoconial crystals in the mutants (black arrowheads). (Scale bar, 500 um.)

Copyright

This image is from Norgett EE, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):13775-80. Copyright 2012 National Academy of Sciences, U.S.A. J:188593

Associated Alleles

Symbol	Name
Atp6v0a4^tm1.1Fekf	ATPase, H+ transporting, lysosomal V0 subunit A4; targeted mutation 1.1, Fiona E Karet Frankl

Associated Genotypes

Allelic Composition	Genetic Background
Atp6v0a4^tm1.1Fekf/Atp6v0a4^tm1.1Fekf	involves: C57BL/6