Phenotype Image Detail

Image

Caption

Gross morphology and survival. (A) Untreated P21 mice: appearance of Atp6v0a4^tm1.1Fekf/Atp6v0a4^tm1.1Fekf, Atp6v0a4^tm1.1Fekf/Atp6v0a4⁺, and wild-type (WT) respectively, Left to Right. (B) Weight: homozygous mutant animals had significantly lower body weight than WT or heterozygous animals. (C) Survival curve over 250 days (WT n = 25; heterozygotes, n = 43; homozygotes, n = 29); only two homozygous animals survived until the end of the census period. (D) Hydronephrotic kidney from a 9-month old homozygous animal (left) in comparison with an age-matched WT normal kidney (right). (Scale bar: 5 mm). Von Kossa staining in a P14 homozygote (E) and an 8-month old homozygote (F) animal, showing early and later medullary nephrocalcinosis. (Scale bars: 20 um.)

Copyright

This image is from Norgett EE, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):13775-80. Copyright 2012 National Academy of Sciences, U.S.A. J:188593

Associated Alleles

Symbol	Name
Atp6v0a4^tm1.1Fekf	ATPase, H+ transporting, lysosomal V0 subunit A4; targeted mutation 1.1, Fiona E Karet Frankl

Associated Genotypes

Allelic Composition	Genetic Background
Atp6v0a4^tm1.1Fekf/Atp6v0a4^tm1.1Fekf	involves: C57BL/6