Phenotype Image Detail

Image

Caption

Enlarged mitochondria in Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe Myl2^tm1(cre)Krc/Myl2⁺ (CKO). (A) Transmission electron microscopy (TEM) sections from wild-type (WT) and mutant (CKO) mouse hearts. Scale bar: 5 um (upper panels), 0.5 um (lower panels). (B) Average mitochondrial area and (C) mitochondrial volume density calculated from TEM slices from 6 pairs of 4-6-month-old mice. n = 700 from 50 slices.

Copyright

This image is from Zhao T, J Biol Chem 2012 Jul 6;287(28):23615-25 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:188865

Associated Alleles

Symbol	Name
Mfn2^tm1.1Mzhe	mitofusin 2; targeted mutation 1.1, Ming Zheng
Myl2^tm1(cre)Krc	myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Kenneth R Chien

Associated Genotypes

Allelic Composition	Genetic Background
Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe Myl2^tm1(cre)Krc/Myl2^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J