Phenotype Image Detail

Image

Caption

Histology and morphometric analysis of lungs in Adra2b^tm1Gsb/Adra2b^tm1Gsb (Adra2b-/-) mice between embryonic day E14.5 and postnatal day P0. A-I, lungs from mutant and wild-type (Adra2b^+/+) mice were obtained from timed matings at the indicated days of development. Morphometric analysis of methylene blue-stained lung sections revealed normal distribution of alveolar/bronchial spaces versus cellular areas during embryonic development (e, f, and i) but increased interalveolar septi and cell areas in mutant lungs on postnatal day P0 (A, alveoli; bars, 20 um, E14.5 and 10 um, E17.5-P0; n = 3-7 per genotype and time point, **, p < 0.01 versus wild-type.

Copyright

This image is from Haubold M, J Biol Chem 2010 Oct 29;285(44):34213-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166788

Associated Alleles

Symbol	Name
Adra2b^tm1Gsb	adrenergic receptor, alpha 2b; targeted mutation 1, Gregory S Barsh

Associated Genotypes

Allelic Composition	Genetic Background
Adra2b^tm1Gsb/Adra2b^tm1Gsb	B6.129-Adra2b^tm1Gsb