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Phenotype Image Detail
Image
Caption Gene trap disruption of Tnrc6a (GW182) leads to embryonic lethality and defects in the yolk sac. A, comparison of control (gt/+) embryos and Tnrc6aGt(XE786)Byg/Tnrc6aGt(XE786)Byg (gt/gt) embryos at E9.5 and E10.5. B, H&E staining and Ki67 immunolabeling of the yolk sac identified impaired hematopoiesis, abnormal endoderm, and reduced cell proliferation in mutant (GW182 gt/gt) embryos at E9.5.
Copyright This image is from Jiang Z, J Biol Chem 2012 Feb 17;287(8):5979-87 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:182447
Associated
Alleles
Symbol Name
Tnrc6aGt(XE786)Byg trinucleotide repeat containing 6a; gene trap XE786, BayGenomics
Associated
Genotypes
Allelic Composition Genetic Background
Tnrc6aGt(XE786)Byg/Tnrc6aGt(XE786)Byg involves: 129P2/OlaHsd * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory