Phenotype Image Detail

Image

Caption

Patent foramen ovale, aortic valve stenosis and pulmonary valve stenosis in Gata4^tm1Grg/Gata4⁺ (Gata4 G295S^ki/wt) murine hearts by histologic section. Interatrial communication in the form of patent foramen ovale (arrowhead in B,D) is found in heterozygous mutant mice (B,D) as compared to wild-type littermate (A,C). (C,D) represent high magnification image of boxed area in (A,B), respectively. Thickening of aortic valve leaflets is found in heterozygous mutant mouse (F) that had aortic valve stenosis by echocardiogram as compared to wild-type (E). Thickened pulmonary valve leaflets in heterozygous mutant mouse are shown (H) as compared to normal leaflets in wild-type littermate (G). RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; AO, aorta; PA, pulmonary artery. Scale bars indicate 200 um.

Copyright

This image is from Misra C, PLoS Genet 2012 May;8(5):e1002690, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185124

Associated Alleles

Symbol	Name
Gata4^tm1Grg	GATA binding protein 4; targeted mutation 1, Vidu Garg

Associated Genotypes

Allelic Composition	Genetic Background
Gata4^tm1Grg/Gata4^+	involves: 129 * C57BL/6