Phenotype Image Detail

Image

Caption

G295S mutation in Gata4 results in cardiomyocyte proliferation defects. Immunofluorescent staining for phosphohistone H3 (red) along with desmin staining for cardiomyocytes (green) demonstrates decreased cardiomyocyte proliferation in Gata4^tm1Grg/Gata4^tm1Grg (Gata4 G295S^ki/ki) mice (B) as compared to wild-type mice (A) in histologic sections of E9.5 hearts. V, ventricle.

Copyright

This image is from Misra C, PLoS Genet 2012 May;8(5):e1002690, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185124

Associated Alleles

Symbol	Name
Gata4^tm1Grg	GATA binding protein 4; targeted mutation 1, Vidu Garg

Associated Genotypes

Allelic Composition	Genetic Background
Gata4^tm1Grg/Gata4^tm1Grg	involves: 129 * C57BL/6