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Phenotype Image Detail
Image
Caption (A) The 4-week-old Fam20ctm1.1Cqi/Fam20ctm1.1Cqi Edil3Tg(Sox2-cre)1Amc/0 (cKO) mouse on the left was smaller compared with the wild-type (WT) littermate on the right. (B) The 4-week-old mutant mouse (left) had flat face (undeveloped nose, a typical manifestation of rickets) compared with the WT littermate (right). (C) Body weight monitoring from newborn (Nb) to postnatal 10 weeks revealed significant growth retardation in the mutant mice. (D) Plain X-ray examination of a 5-month-old mutant mouse (left) revealed smaller skeleton, hypomineralization and distorted spine (arrowheads) compared with its WT littermate (right).
Copyright This image is from Wang X, PLoS Genet 2012 May;8(5):e1002708, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185208
Associated
Alleles
Symbol Name
Edil3Tg(Sox2-cre)1Amc EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Fam20ctm1.1Cqi family with sequence similarity 20, member C; targeted mutation 1.1, Chunlin Qin
Associated
Genotypes
Allelic Composition Genetic Background
Fam20ctm1.1Cqi/Fam20ctm1.1Cqi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory