Phenotype Image Detail

Image

Caption

Neurodegenerative changes in forebrain neuron-specific knockout of Xpa in Ercc6^tm1Gvh/Ercc6^tm1Gvh (Csb^-/-) mice. Representative photomicrographs (B, C), of ATF3 (B), and active caspase 3 (C) staining in the cortex of 65 week old Ercc6^tm1Gvh/Ercc6^tm1Gvh (Csb^-/-) and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Csb^-/- Xpa^c/- CamKII-Cre⁺) mice showing an increase in the number of p53- and ATF3 immunoreactive cells and the appearance of caspase 3 labeled neurons in the cortex of Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 mice. Callibration Bars: 100 (B1), 25 um (C1).

Copyright

This image is from Jaarsma D, PLoS Genet 2011 Dec;7(12):e1002405, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179808

Associated Alleles

Symbol	Name
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Tg(Camk2a-cre)1Szi	transgene insertion 1, Scott Zeitlin
Xpa^tm1Gvh	xeroderma pigmentosum, complementation group A; targeted mutation 1, Gijsbertus T J van der Horst
Xpa^tm1Hvs	xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg

Associated Genotypes

Allelic Composition	Genetic Background
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0	involves: 129P2/OlaHsd * C57BL/6J * CBA