Phenotype Image Detail

Image

Caption

Early postnatal (P5 and P10) germ cell depletion in male and female Mirc5^tm1Jae/Mirc5^tm1Jae (mir-290-295-/-) mice. (A and B) Hematoxylin and eosin-stained sections from wild-type (WT) (A) and Mirc5^tm1Jae/Mirc5^tm1Jae (B) P5 ovaries. (C and D) Mouse vasa homolog (MVH)-stained sections from WT (C) and mutant (D) P5 ovaries. Arrows in D point to primordial follicles; arrowheads point to growing follicles. (E and F) Hematoxylin and eosin-stained sections from WT (E) and mutant (F) P10 ovaries. (G and H) MVH-stained sections from WT (G) and mutant (H) P10 ovaries. Arrows point to the primordial follicle pool. Note the absence of the primordial follicle pool in the mutant. (I and J) Hematoxylin and eosin-stained sections from WT (I) and mutant (J) P5 testes. (K and L) MVH-stained sections from WT (K) and mutant (L) P5 testes. (M and N) Hematoxylin and eosin-stained sections from WT (M) and mutant (N) P10 testes. (O and P) MVH-stained sections from WT (O) and mutant (P) P10 testes. (Scale bars, 100 uM.)

Copyright

This image is from Medeiros LA, Proc Natl Acad Sci U S A 2011 Aug 23;108(34):14163-8. Copyright 2011 National Academy of Sciences, U.S.A. J:175228

Associated Alleles

Symbol	Name
Mirc5^tm1Jae	microRNA cluster 5, including Mir290a through Mir295; targeted mutation 1, Rudolf Jaenisch

Associated Genotypes

Allelic Composition	Genetic Background
Mirc5^tm1Jae/Mirc5^tm1Jae	involves: 129S4/SvJae * C57BL/6