Phenotype Image Detail

Image

Caption

Phenotypic analysis and X-gal staining of Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} mice. (a & b) Low power magnification of H&E stained eyes revealed that Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} mutant eyes were grossly normal but that overall eye size was reduced. (c & d) Higher magnification analysis revealed normal organization and retinal cell-layer lamination in mutant eyes. Abbreviations: c, cornea; ln, lens; r, retina; gcl, ganglion cell layer; inl, inner nuclear layer; onl, outer nuclear layer; rpe, retinal pigmented epithelium (Scale bars: a & b = 250 um; c, d & e = 100 um). (e) Maximum width measurements were taken for optic nerves (on) of mutants (n = 17) and controls (n = 11) from paraffin-embedded sections (f) This plot shows the significantly smaller mean diameter of the optic nerve in mutants compared to control animals with the error bars representing the non-overlapping of 95% confidence limits; 125.7 um (118.2-133.3) and 147.0 um (139.6-154.5) respectively.

Copyright

This image is from Rainger J, PLoS Genet 2011 Jul;7(7):e1002114, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174198

Associated Alleles

Symbol	Name
Smoc1^tm1a(EUCOMM)Wtsi	SPARC related modular calcium binding 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Smoc1^tm1a(EUCOMM)Wtsi	SPARC related modular calcium binding 1; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Smoc1^tm1a(EUCOMM)Wtsi/Smoc1^tm1a(EUCOMM)Wtsi	C57BL/6N-Smoc1^tm1a(EUCOMM)Wtsi