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Phenotype Image Detail
Caption (D) Quantification of filopodium length (n = 18 per group) and filopodium number/100 um vessel length (n = 7 per group) at the sprouting vascular fronts, and vascular density (n = 4 per group) in P4 controls and Sema3etm1Ddg/Sema3etm1Ddg (Sema3e-/-) retinas. Error bars represent SEM; ***p < 0.001, *p < 0.05. (E) Triple labeling for neurofilaments (green), PECAM-1 (red), and nuclei (blue) in retinal sections of P4 mutant mice. The superficial vessels (arrowheads) over the neuronal axons ectopically invade the ganglion cell layer (GCL) of the homozygous mutant mice (arrow). Scale bars: 20 um (E).
Copyright This image is from Fukushima Y, J Clin Invest 2011 May 2;121(5):1974-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173943
Symbol Name
Sema3etm1Ddg sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, David D Ginty
Allelic Composition Genetic Background
Sema3etm1Ddg/Sema3etm1Ddg involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory