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Phenotype Image Detail
Caption (A) Representative histological findings in Col4a3tm1Dec/Col4a3tm1Dec mice (wild-type for Sostdc1, but mutant for Col4a3; WT/KO) and Sostdc1tm1Myan/Sostdc1tm1Myan Col4a3tm1Dec/Col4a3tm1Dec mice (KO/KO) at 6 weeks and 10 weeks of age. Scale bars: 100 um. (B and C) Quantitative assessment of the number of glomeruli, percentages of sclerotic and hemorrhagic glomeruli, and tubulointerstitial fibrosis score in Col4a3tm1Dec/Col4a3tm1Dec (WT/KO) and Sostdc1tm1Myan/Sostdc1tm1Myan Col4a3tm1Dec/Col4a3tm1Dec(KO/KO) mice at 6 weeks (B, n = 5) and 10 weeks of age (C, n = 10). Bars indicate the mean +/- SD. **P < 0.01; ***P < 0.05. (D) Electron microphotographs in WT/KO and KO/KO mice at 4 weeks and 10 weeks of age. Arrows indicate the splitting of the glomerular basement membrane. Scale bars: 5 um. (E) Immunostaining for alpha1(IV) and alpha3(IV) collagen in the glomeruli of wild-type littermates (WT/WT), WT/KO, and KO/KO mice at 6 weeks of age. Podocin was used as a podocyte marker. Note the positive staining for alpha1(IV) collagen along with the glomerular basement membrane of WT/KO and KO/KO mice, while the staining is restricted to mesangial areas in the glomeruli of wild-type littermates.
Copyright This image is from Tanaka M, J Clin Invest 2010 Mar;120(3):768-77 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158731
Symbol Name
Col4a3tm1Dec collagen, type IV, alpha 3; targeted mutation 1, Dominic Cosgrove
Sostdc1tm1Myan sclerostin domain containing 1; targeted mutation 1, Motoko Yanagita
Allelic Composition Genetic Background
Col4a3tm1Dec/Col4a3tm1Dec 129-Col4a3tm1Dec/J
involves: 129X1/SvJ

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