Phenotype Image Detail

Image

Caption

Gross and histological analysis of postnatal testes. (A) Gross analysis of testes from 7 week old littermates. (B-M) Histological analysis of Asz1^tm1Zuk/Asz1⁺ (+/-) and Asz1^tm1Zuk/Asz1^tm1Zuk (-/-) mice. (M) is a higher power magnification of (L) to show the lack of germ cells attached to the base of the tubule and sloughing germ cells in the lumen. G, spermatogonia; L, leptotene spermatocytes; M, meiotically dividing spermatocytes; Mit, mitotically dividing spermatogonia; P, pachytene spermatocytes; PL, preleptotene spermatocytes; Ser, Sertoli cells; Z, zygotene spermatocytes; dying spermatocytes with compact chromatin (red arrowhead); and with diffuse chromatin (open arrowhead); sloughing germ cells (black arrowheads). [Scale bars: 100 um (B-C), 20 um (D-K).]

Copyright

This image is from Ma L, PLoS Genet 2009 Sep;5(9):e1000635, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:152071

Associated Alleles

Symbol	Name
Asz1^tm1Zuk	ankyrin repeat, SAM and basic leucine zipper domain containing 1; targeted mutation 1, Martin M Matzuk

Associated Genotypes

Allelic Composition	Genetic Background
Asz1^tm1Zuk/Asz1^tm1Zuk	involves: 129 * C57BL/6