Phenotype Image Detail

Image

Caption

Newborn mice were stained with alcian blue/alizarin red and cleared with KOH. (A) Inferior view of skull base after removal of the mandible. Anterior is to the top. The upper 2 circles are photographs. In the Bnc2^{Gt(pU21)18Imeg}/Bnc2⁺ mouse, the maxillary and palatine processes have converged toward the midline. In the Bnc2^{Gt(pU21)18Imeg}/Bnc2^{Gt(pU21)18Imeg} mouse, both processes are absent thus exposing the vomer and presphenoid. The internal pterygoid processes of the mutant mouse have failed to develop caudally. The lower 2 circles are schematic representations. Bone processes that have failed to grow in the mutant mouse are outlined in red. Arrows indicate direction of axial and rostral growths that did not occur. Al, alisphenoid; BS, basisphenoid; ePp, external pterygoid process; iPp, internal pterygoid process; M, maxillary; Mp, maxillary process; PL, palatine bone; PM, premaxillary; PS, presphenoid; S, sphenoid; V, vomer. (B) Superior view of skull showing that sutures and posterior fontanel are abnormally large in the homozygous mutants. (C) Shorter stature of mutant and absence of gross skeletal abnormalities. Tails have been cut for genotyping.

Copyright

This image is from Vanhoutteghem A, Proc Natl Acad Sci U S A 2009 Aug 25;106(34):14432-7. Copyright 2009 National Academy of Sciences, U.S.A. J:151992

Associated Alleles

Symbol	Name
Bnc2^Gt(pU21)18Imeg	basonuclin zinc finger protein 2; gene trap 18, Institute of Molecular Embryology and Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Bnc2^Gt(pU21)18Imeg/Bnc2^Gt(pU21)18Imeg	involves: C57BL/6 * CBA