Phenotype Image Detail

Image

Caption

A and B, immunoperoxidase staining for peroxisomal ACOX in liver of wild-type (+/+) mouse (A) and Acox1^tm1Jkr/Acox1^tm1Jkr (-/-) mouse (B) fed a diet containing 0.0125% ciprofibrate, a peroxisome proliferator, for 1 week. Intense cytoplasmic granular staining for ACOX is seen in the liver of wild-type mouse, but is absent in the mutant mouse. Low magnification, histological appearance of liver (hematoxylin and eosin-stained sections) of wild-type mouse (C) and 2 month-old mutant mice (D). Hepatic parenchymal cells of young mutant mice reveal severe steatosis involving the entire liver lobule (D). Numerous microvesicular fatty droplets are seen in the cytoplasm (E and F) of 4-5 month old mutant mice; liver cell death and lipogranulomas are also observed (arrows point to lipogranulomas in E and F). Focal proliferations of hepatocytes with intensely eosinophilic, granular cytoplasm (arrows) are also seen in the steatotic livers of 5-7 month old mutant mice (G).

Copyright

This image is from Fan CY, J Biol Chem 1996 Oct 4;271(40):24698-710 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:35794

Associated Alleles

Symbol	Name
Acox1^tm1Jkr	acyl-Coenzyme A oxidase 1, palmitoyl; targeted mutation 1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Acox1^tm1Jkr/Acox1^tm1Jkr	involves: 129P2/OlaHsd * C57BL/6J